Preparation of chiral primary amine from asymmetric reductive amination of simple ketone catalyzed by ruthenium-diphosphine catalyst
US12145897B2 · kind B2 · utility
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Key dates
| Filing date | Jul 30, 2021 |
| Grant date | Nov 19, 2024 |
| Priority date | — |
| Expiry date | Apr 13, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2602/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to a preparation method of chiral primary amine. The chiral primary amine is prepared through a one-pot method that under the action of a ruthenium-chiral diphosphine catalyst, a simple ketone and an ammonium salt RCOONH4 have reductive amination by adding hydrogen and then are heated and hydrolyzed by adding acid. The present invention has the advantages of good substrate universality, high reaction efficiency and the like
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.