Imidazopyrimidines as EED inhibitors and the use thereof

US12145944B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Shaomeng Wang · Saline, US
• Rohan Rej · Ann Arbor, US
• Changwei Wang · Beijing, CN
• Mi Wang · Fremont, US
• Jianfeng Lu · Ann Arbor, US
• Chao-Yie Yang · Hangzhou City, CN
• Ester Fernandez-Salas · San Mateo, US
• Jeanne Stuckey · Fenton, US

Key dates

• Filing date: Jul 16, 2020
• Grant date: Nov 19, 2024
• Expiry date: Dec 24, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/6561
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides compounds represented by Formula I: wherein R1, R2, R3, and R4 are as defined in the specification, and the salts and solvates thereof. Compounds of Formula I are EED inhibitors. EED inhibitors are useful for the treatment of cancer and other diseases.