Polymyxin compounds and uses thereof
US12146004B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 26, 2015 |
| Grant date | Nov 19, 2024 |
| Priority date | — |
| Expiry date | Nov 26, 2035 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a compound of formula (I), and its use in methods of treatment, including the treatment of bacterial infections. Methods for the preparation of the compound of formula (I) are also provided. The compound of formula (I) has the structure shown below, where —R6 and —R7 are each together with the carbonyl group and nitrogen alpha to the carbon to which it is attached an amino acid residue, except that R6 together with the carbonyl group and nitrogen alpha to the carbon to which it is attached is not a phenylalanine, leucine or valine residue and/or —R7 together with the carbonyl group and nitrogen alpha to the carbon to which it is attached is not a leucine, iso-leucine, phenylalanine, threonine, valine or nor-valine residue, and -T, -A1, -A2, -A3 and —R10 are as discussed in the application:
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.