Patent · US Active

Vascularized cardiac organoid with a chamber structure and its preparation method

US12146163B2 · kind B2 · utility

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0References

5Claims

0Family size

Assignee

Nankai University · CN

Inventors

Deling Kong · Tianjin, CN
Zhuangzhuang YANG · Wuxi, CN
Songdi WANG · Tianjin, CN

Key dates

Filing date	Oct 19, 2023
Grant date	Nov 19, 2024
Priority date	—
Expiry date	Oct 19, 2043

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2513/00
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

A vascularized cardiac organoid with a chamber structure and its preparation method is presented. The cardiac organoids have a unique chamber structure, which includes a myocardium wall. Within the cardiac organoids, a vascular network is developed, enclosed within the myocardium wall. This vascular network is composed of endothelial cells surrounded by smooth muscle cells, forming a network of branched tubular structures. The presence of vasculature significantly promotes the arrangement of the myocardium, enhances the organization of the cardiac cytoskeleton, and promotes the consistency and beating frequency of cardiac cells. The vasculature facilitates the growth and size increase of the cardiac organoids.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.