Patent · US Active

HiC: method of identifying regulatory interactions between genomic loci

US12146186B2 · kind B2 · utility

0Cited by

7References

20Claims

0Family size

Assignees

Presidents and Fellows of Harvard University · US
Massachusetts Institute of Technology · US
Whitehead Institute For Biomedical Research · US
University of Massachusetts · US

Inventors

Job Dekker · Princeton, US
Erez Lieberman Aiden · Cambridge, US
Nynke Van Berkum · The Hague, NL
Andreas Gnirke · Wellesley, US
Eric S. Lander · Cambridge, US
Chad Nusbaum · Newton, US
Louise Williams · Reading, US
Alexandre Melnikov · Bellingham, US
Georgia Giannoukos · Cambridge, US

Key dates

Filing date	Aug 11, 2020
Grant date	Nov 19, 2024
Priority date	—
Expiry date	Aug 24, 2043

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Q1/68
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The disclosed Hi-C protocol can identify genomic loci that are spatially co-located in vivo. These spatial co-locations may include, but are not limited to, intrachromosomal interactions and/or interchromosomal interactions. Hi-C techniques may be applied to many different scales of interest. For example, on a large scale, Hi-C techniques can be used to identify long-range interactions between distant genomic loci.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.