Methods and compositions for analyte quantification
US12146869B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 14, 2023 |
| Grant date | Nov 19, 2024 |
| Priority date | — |
| Expiry date | Jul 14, 2043 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/045
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Disclosed are methods, libraries, and samples for quantifying a target analyte in a laboratory sample including the target analyte. The methods typically include the step of estimating the amount of the target analyte in the laboratory sample from mass spectrometric data including signal intensities for the target analyte and one or more internal standards, where the mass spectrometric data are an output of a mass spectrometric analysis of a target sample produced from the laboratory sample and a predetermined amount of the one or more internal standards. The present disclosure also provides a method for analyte quantification. The method comprises adding one or more calibrators to a sample comprising one or more analytes; applying mass spectrometry (MS) to the sample; and using a trained machine learning model to determine an absolute concentration of the one or more analytes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.