D-glucose and its analogs as tracers to assess the glucose transporter function on blood-cerebrospinal fluid barrier and the functioning of the brain lymphatic system
US12150750B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Apr 7, 2021 |
| Grant date | Nov 26, 2024 |
| Priority date | — |
| Expiry date | Jul 31, 2041 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01R33/4833
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method of assessing the brain lymphatic or glymphatic system and the glucose transporter function on blood-cerebrospinal fluid barrier (BCSFB) of a subject using D-glucose or a D-glucose analog. A spatial map is generated of water MR signals that are sensitized to changes in D-glucose or a D-glucose analog in cerebrospinal fluid (CSF) of the subject. The spatial map is observed at one or more time points before, one or more time points during, and one or more time points after, raising the blood level of the D-glucose or a D-glucose analog in the subject CSF. A difference is detected between the MR signals of the spatial map before, during, and after raising the blood level of D-glucose or a D-glucose analog. A physiological parameter associated with the brain lymphatic or glymphatic system and the glucose transporter function on BCSFB of the subject is ascertained based on the detected difference.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.