Formulation for administration of RNA

US12150947B2 · kind B2 · utility

Assignees

• BIONTECH SE · DE
• TRON—Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz · DE

Inventors

• Ugur Sahin · Mainz, DE
• Heinrich Haas · Mainz, DE
• Annette Vogel · Mainz, DE
• Stephanie Erbar · Mainz, DE
• Kerstin Walzer · Seeheim-Jugenheim, DE
• Anne Schlegel · Mainz, DE
• Sebastian Hörner · Mainz, DE
• Jorge Herrero Moreno · Mainz, DE
• Thorsten Klamp · Mainz, DE
• Sebastian Kreiter · Mainz, DE
• Mustafa Diken · Mainz, DE
• Phillip Heller · Mainz, DE

Key dates

• Filing date: Jan 10, 2019
• Grant date: Nov 26, 2024
• Expiry date: May 25, 2040

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/26
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compositions comprising polyplex formulations for delivery of RNA to a target organ or a target cell after parenteral administration, in particular after intramuscular administration. More precisely, the present invention relates to formulations for administration of RNA such as self-replicating RNA, in particular by intramuscular injection. In more detail, the formulations comprise polyplex particles from single stranded RNA and a polyalkyleneimine.