Polymeric prodrugs and subcutaneous and/or intramuscular administration thereof
US12150996B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Nov 16, 2018 |
| Grant date | Nov 26, 2024 |
| Priority date | — |
| Expiry date | Nov 16, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08F2438/03
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to new prodrugs of active molecules. These prodrugs allow, in particular, the subcutaneous or intramuscular administration of active molecules of which the subcutaneous or intramuscular administration is problematic or impossible, in particular because of the toxicity at the injection site. The prodrugs according to the invention comprise an active ingredient, covalently linked with a polymer chain, preferably a hydrophilic and/or thermosensitive polymer chain.The invention relates, in particular, to polymeric prodrugs comprising a polymer chain formed at least in part by acrylamide monomer or one of its derivatives, said polymer comprising a proximal part and a terminal part; a first pharmaceutically active molecule covalently coupled to the proximal part of the polymer; possibly a second pharmaceutically active molecule covalently coupled to the terminal part of the polymer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.