Polymer microneedle mediated drug delivery
US12151074B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 27, 2019 |
| Grant date | Nov 26, 2024 |
| Priority date | — |
| Expiry date | Feb 25, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/89
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of providing therapeutic treatment by delivering therapeutic aptamers locally to a target site using microneedles includes providing complementary sequence modified microneedles by reacting a complementary sequence (CS) with a polymer thereby forming a covalent bond between the polymer and the CS, forming microneedle patches using an initial casting solution consisting of the polymer, the therapeutic aptamer, and a covalent bond between a complementary sequence (CS) and the polymer, thereby loading the therapeutic aptamer into the microneedles, each microneedle having a base, shaft and tip, physically binding the therapeutic aptamer to the CS, inserting the microneedles into the tissue such that the tips and shafts are embedded into the target site and the bases are on a surface of the target site, and sustained release of the aptamer to the target site due to dissociation of the aptamer from the CS over time.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.