Ketoamide compound and preparation method, pharmaceutical composition, and use thereof

US12152017B2 · kind B2 · utility

Assignees

• SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES · CN
• FUDAN UNIVERSITY · CN

Inventors

• Hong Liu · Shanghai, CN
• Shibo Jiang · Floral Park, US
• Wenhao Dai · Chengdu, CN
• Lu Lu · San Diego, US
• Jingjing PENG · Shanghai, CN
• Shuai XIA · Shanghai, CN
• Jiang Wang · Shanghai, CN
• Jian Li · Shanghai, CN
• Hualiang Jiang · Shanghai, CN
• Kaixian Chen · Shanghai, CN

Key dates

• Filing date: Aug 9, 2019
• Grant date: Nov 26, 2024
• Expiry date: Mar 21, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A ketoamide compound and a preparation method, a pharmaceutical composition, and a use thereof. Specifically, the ketoamide compound shown in formula (A), a racemate, an enantiomer, or a diastereoisomer thereof, or any mixture of same, or a pharmaceutically active metabolite thereof, or a pharmaceutically acceptable salt, solvate, or prodrug thereof. The ketoamide compound can effectively inhibit coronavirus or Ebola virus, and thereby implement the prevention or treatment of diseases related to coronavirus or diseases related to Ebola virus.