Nucleic acid molecules and applications thereof in human antibody
US12152069B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 16, 2018 |
| Grant date | Nov 26, 2024 |
| Priority date | — |
| Expiry date | Mar 16, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2015/8518
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Nucleic acid molecules include immunoglobulin genes or parts of immunoglobulin genes. The nucleic acid molecules includes the IgM gene (IgHCμ) and IgM switch region (Sμ). The sequences of the Sμ and the IgHCμ are both derived from a transgenic host animal. In this invention, human antibodies are directly generated and no humanization process is required, and the human antibody druggability is increased. The transgenic human antibody mouse has normal early B−cell development, maturation and the B−cell number in comparison with that of wild type animal, thereby facilitating the differentiation of the B−cells. The specificity and diversity of the produced antibody are improved; and the efficiency for screening the therapeutic antibody is improved.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.