Chimeric antigen receptors targeting CD70

US12152081B2 · kind B2 · utility

Assignee

• PFIZER INC. · US

Inventors

• Surabhi Srivatsa Srinivasan · San Francisco, US
• Niranjana Nagarajan · Oakland, US
• Siler PANOWSKI · Berkeley, US
• Yoon Kyung Park · Sani-myeon, KR
• Tao Sai · Foster City, US
• Barbra Johnson SASU · San Francisco, US
• Thomas John VAN BLARCOM · Oakland, US
• Mathilde Brunnhilde Dusseaux · Créteil, FR
• Roman Galetto · Paris, FR

Key dates

• Filing date: Jun 17, 2022
• Grant date: Nov 26, 2024
• Expiry date: Jul 7, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/33
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The disclosure provides CARs (CARs) that specifically bind to CD70. The disclosure further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The disclosure further relates to therapeutic methods for use of these CARs and engineered immune cells comprising these CARs for the treatment of a condition associated with malignant cells expressing CD70 (e.g., cancer).