Methods for predicting the usefulness of proteins or protein fragments for immunotherapy

US12153041B2 · kind B2 · utility

Assignees

• TRON—Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz · DE
• BIONTECH SE · DE

Inventors

• Mathias Vormehr · Mainz, DE
• Ugur Sahin · Mainz, DE
• Barbara Schrörs · Mainz, DE
• Martin Löwer · Bodenheim, DE
• Sebastian Boegel · Obermoschel, DE

Key dates

• Filing date: May 10, 2017
• Grant date: Nov 26, 2024
• Expiry date: May 17, 2038

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/52
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention relates to methods for predicting peptides or polypeptides such as T cell epitopes useful for immunotherapy such as for vaccination. In particular, the present invention relates to methods for predicting whether peptides or polypeptides such as tumor-associated antigens or epitopes, in particular tumor-associated neoantigens or neoepitopes, are immunogenic and, in particular, useful for immunotherapy such as for vaccination. The methods of the invention may be used, in particular, for the provision of vaccines which are specific for a patient's tumor and, thus, in the context of personalized cancer vaccines.