Antibiotic therapy guidance based on procalcitonin in patients with comorbidities

US12153057B2 · kind B2 · utility

Assignee

• B.R.A.H.M.S GMBH · DE

Inventors

• Darius Wilson · Lörrach, DE
• Stefan Kirsch · Heidesheim, DE

Key dates

• Filing date: Dec 20, 2018
• Grant date: Nov 26, 2024
• Expiry date: Feb 17, 2040

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/52
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A method for antibiotic therapy guidance, stratification and/or control in a patient with one or more comorbidities comprising an impaired innate immune response and suspected of having an infection. Also, a method for antibiotic therapy guidance, stratification and/or control in a patient with one or more comorbidities comprising an impaired innate immune response, wherein the comorbidity is preferably selected from the group comprising metabolic disorder (obesity), diabetes, hypertension, renal disease, thrombosis, malignancy or cancer, and suspected of having an infection. In particular, the method comprises providing a sample from said patient and determining a level of PCT or fragment(s) thereof in said sample, wherein the level of PCT or fragment(s) thereof in said sample is indicative of whether an initiation or a change of an antibiotic treatment is required. Furthermore, a kit for carrying out the method of the present invention.