Antibody drug conjugates comprising sting agonists

US12156870B2 · kind B2 · utility

Assignee

• Mersana Therapeutics, Inc. · US

Inventors

• Jeremy R. DUVALL · Topsfield, US
• Keith W. BENTLEY · Everett, US
• Raghida BUKHALID · Melrose, US
• Naniye CETINBAS · Somerville, US
• Marc I. DAMELIN · Park Ridge, US
• Eugene Kelleher · Somerville, US
• Timothy B. Lowinger · Carlisle, US
• Joshua D. Thomas · Natick, US
• Dorin Toader · Cambridge, US
• Ling Xu · Potomac, US
• Liping Yang · Arlington, US

Key dates

• Filing date: Dec 20, 2022
• Grant date: Dec 3, 2024
• Expiry date: Dec 20, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/71
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides scaffolds and antibody-drug conjugates (ADCs) comprising a stimulator of interferon genes (STING). The present disclosure also provides uses of the ADCs in treatment, e.g., treatment of cancer.