Patent · US Active

Thioesterase variants having improved activity for the production of medium-chain fatty acid derivatives

US12157904B2 · kind B2 · utility

0Cited by

0References

14Claims

0Family size

Assignee

Genomatica, Inc. · US

Inventors

Angelica Zabala BAUTISTA · San Diego, US
Min Sun PARK · San Diego, US
Alma Itzel RAMOS-SOLIS · San Diego, US
Bernardo Moura TORRES DA COSTA · San Diego, US
Behnaz Behrouzian · South San Francisco, US
Donald E. Trimbur · Palo Alto, US
Emanuela Popova · South San Francisco, US
Qijun HU · San Diego, US
Stephen del Cardayre · South San Francisco, US

Key dates

Filing date	Apr 7, 2022
Grant date	Dec 3, 2024
Priority date	—
Expiry date	May 3, 2042

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y301/02014
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The disclosure relates to engineered plant acyl-ACP thioesterases having improved activity for the production of medium-chain fatty acid derivatives including e.g., eight carbon and ten carbon fatty acids and fatty acid derivatives. The disclosure further relates to recombinant host cells comprising the engineered plant acyl-ACP thioesterases having improved activity for the production of medium-chain fatty acid derivatives. The disclosure also relates to methods of decreasing toxicity and improving production of medium-chain fatty acids and derivatives.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.