Electrochemical biosensor array devices, systems, and methods for point-of-care detection

US12157914B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Drew Hall · Village of La Jolla, US
• Chung-Lun Hsu · San Jose, US
• Alexander Sun · Oakland, US
• Yunting Zhao · San Diego, US
• Eliah Aronoff-Spencer · Village of La Jolla, US

Key dates

• Filing date: Feb 28, 2019
• Grant date: Dec 3, 2024
• Expiry date: Feb 10, 2042

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N27/028
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Disclosed are biosensor devices, systems, and methods for point-of-care applications. In some aspects, a biosensor system includes a biosensor chip device to measure impedance at an electrode-electrolyte interface, which includes an electrochemical sensor comprising a first electrode including a functionalization layer exposing a molecular binding site to bind a target molecule for detection and a second electrode that does not include the binding site, and an electronic circuit unit corresponding to each electrode of the electrochemical sensor including a transimpedance amplifier, a phase detector to determine a relative phase shift in the detected electrical signal caused by an impedance change from a binding event of the target molecule at the molecular binding site, and a time-to-digital converter to quantize and average phase data points in time to remove uncorrelated noise from the detected electrical signal; and a signal generator to produce an electrical excitation signal applied across the electrode-electrolyte interface.