Antibodies against dengue virus and related methods

US12161890B2 · kind B2 · utility

Assignees

• CZ Biohub SF, LLC · US
• The Board of Trustees of the Leland Stanford Junior University · US

Inventors

• Fabio Zanini · Stanford, US
• Derek Croote · Stanford, US
• Makeda L. Robinson · Stanford, US
• Leslie Goo · San Francisco, US
• Stephen R. Quake · Pasadena, US
• Shirit Einav · Stanford, US
• Krista McCutcheon · Burlingame, US
• Eric Waltari · San Francisco, US

Key dates

• Filing date: Aug 7, 2019
• Grant date: Dec 10, 2024
• Expiry date: Nov 11, 2041

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/185
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Provided are antibodies or antigen binding portions thereof that specifically bind Dengue virus, various compositions of such antibodies or antigen binding portions thereof, and methods of their use. Provided are such antibodies, fragments of such antibodies retaining Dengue virus-binding ability, pharmaceutical compositions including such antibodies or antigen binding fragments thereof, and diagnostic compositions including such antibodies or antigen binding fragments thereof. Also provided are isolated nucleic acids encoding such antibodies, amino acid sequences of such antibodies, and host cells transformed therewith. Additionally, provided are prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the disclosure.