Tetrahydroquinolino derivatives for the treatment of metastatic and chemoresistant cancers
US12162855B2 · kind B2 · utility
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2Claims
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Key dates
| Filing date | Jan 29, 2021 |
| Grant date | Dec 10, 2024 |
| Priority date | — |
| Expiry date | Mar 22, 2043 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed herein are compounds of Structural Formula I. Compounds of Structural Formula I inhibit aldehyde dehydrogenase isoform Ia3 (ALDHIa3) and are useful for treating cancer, for example, metastatic or chemoresistant cancer, such as metastatic cancer resistant to chemotherapy. Also disclosed herein are compositions comprising compounds of Structural Formula I and uses of compounds of Structural Formula I for treating cancer, for example, metastatic or chemoresistant cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.