NLRP3 inflammasome inhibitors
US12168012B2 · kind B2 · utility
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19Claims
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Assignee
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Key dates
| Filing date | Jul 23, 2019 |
| Grant date | Dec 17, 2024 |
| Priority date | — |
| Expiry date | Sep 9, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D515/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to novel thienopyrrolotriazinacetamide compounds of Formula (I): wherein R1, R2 and R3 are defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to the processes for their preparation, pharmaceutical compositions and medicaments containing them, and their use in the treatment of diseases and disorders mediated by NLRP3.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.