Methods and compositions for CNS delivery of arylsulfatase A
US12168041B2 · kind B2 · utility
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34References
6Claims
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Key dates
| Filing date | Mar 24, 2020 |
| Grant date | Dec 17, 2024 |
| Priority date | — |
| Expiry date | Oct 14, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y310/01001
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an arylsulfatase A (ASA) protein, salt, and a polysorbate surfactant for the treatment of Metachromatic Leukodystrophy Disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.