Forms of aticaprant

US12171743B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Philippe Fernandes · Turnhout, BE
• Mark Schmidt · Ekeren, BE
• Vanina Popova · Nijlen, BE
• Adam Savitz · Greenwich, US
• Rama Melkote · Jalan Pedongkelan, US
• Wayne C. Drevets · Titusville, US
• Srihari Gopal · Montgomery, US
• Darrel Pemberton · Zwaneven, BE
• Chakradhar Lagishetty · King of Prussia, US
• Iva Kezic · Ekeren, BE

Key dates

• Filing date: May 31, 2024
• Grant date: Dec 24, 2024
• Expiry date: May 31, 2044

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The disclosure provides crystalline and amorphous forms of aticaprant. Also provided by the disclosure are pharmaceutical compositions comprising the amorphous or crystalline forms, methods of treating major depressive disorder using the amorphous or crystalline forms of aticaprant, amorphous or crystalline forms of aticaprant for use in the treatment of major depressive disorder in a human patient having anhedonia, uses of the amorphous or crystalline forms of aticaprant in the manufacture of a medicament for the treatment of major depressive disorder, and packages or pharmaceutical products comprising (i) amorphous or crystalline forms of aticaprant and (ii) instructions for treating major depressive disorder. In some aspects, the human patient treated as described herein has anhedonia.