Liposome composition comprising liposomal prodrug of mitomycin c and method of manufacture
US12171746B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jan 11, 2020 |
| Grant date | Dec 24, 2024 |
| Priority date | — |
| Expiry date | Jan 1, 2042 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K45/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A liposome composition comprising a lipophilic prodrug of mitomycin C having an improved pharmacokinetic profile is described. A method for preparing the composition with a solvent system comprised of ethanol and tertiary butanol mixed at an adequate ratio is also described. In an embodiment, the liposome composition is a population of lipid nanoparticles and a pharmaceutically acceptable vehicle, wherein the population of lipid nanoparticles is comprised of a first fraction of spherical liposomes and a second fraction of rod-shaped lipid nanoparticles, where the second fraction is less than about 15% of the population of lipid nanoparticles.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.