Penicillin-binding protein inhibitors

US12173018B2 · kind B2 · utility

Assignee

• VENATORX PHARMACEUTICALS, INC. · US

Inventors

• Christopher J. Burns · Vivonne Bay, AU
• Denis DAIGLE · Street, US
• Guo-Hua Chu · Wilmington, US
• Jodie HAMRICK · New Holland, US
• Steven A. Boyd · Longmont, US
• Allison L. Zulli · Wayne, US
• Eugen F. Mesaros · Wallingford, US
• Stephen M. Condon · Glenmoore, US
• Robert E. Lee TROUT · Collegeville, US
• Cullen L. MYERS · Exton, US
• Zhenrong Xu · Forest Park, US

Key dates

• Filing date: May 23, 2019
• Grant date: Dec 24, 2024
• Expiry date: Jan 11, 2042

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.