Virus and antigen conjugation

US12173328B2 · kind B2 · utility

Assignee

• KBIO HOLDINGS LIMITED · GB

Inventors

• Leigh Burden · Owensboro, US
• Steven D. Hume · Owensboro, US
• Joshua D. Morton · Evansville, US
• Greg Pogue · Austin, US
• Barry Bratcher · Owensboro, US
• Hugh A. Haydon · Louisville, US
• Carrie A. Simpson · Evansville, US
• Nick Partain · Owensboro, US
• John W. Shepherd · Owensboro, US

Key dates

• Filing date: Sep 23, 2022
• Grant date: Dec 24, 2024
• Expiry date: Sep 23, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2770/40063
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Various embodiments disclosed herein include methods and exemplary compositions associated with conjugation of virus and proteins (e.g., antigen) to form vaccines for delivery of immunological and other therapeutic agents, exemplary aspects of which may include harvesting viral and antigenic substances from source organisms; purifying the viral and protein (e.g. antigenic, including influenza hemagglutinin antigens) substances through methodologies described in an exemplary manner, as well as their concentration and collection; and a conjugation platform providing activation of the virus at a pH that increases binding rate and binding propensity between the virus and the protein, wherein embodiments related to the conjugation platform include controlling the ratio of virus to protein.