Lung protease nanosensors and uses thereof

US12173349B2 · kind B2 · utility

Assignee

• Massachusetts Institute of Technology · US

Inventors

• Sangeeta N. Bhatia · Lexington, US
• Jesse C. Kirkpatrick · Mission Viejo, US
• Jaideep S. Dudani · Boston, US
• Colin Buss · Cambridge, US
• Andrew David Warren · Cambridge, US

Key dates

• Filing date: Sep 25, 2019
• Grant date: Dec 24, 2024
• Expiry date: Nov 6, 2040

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/12
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Aspects of the present disclosure relate to methods and compositions useful for in vivo and/or in vitro profiling of proteases present in the lung. In some embodiments, the disclosure provides methods of in vivo enzymatic processing of exogenous molecules followed by detection of detectable markers as representative of the presence of active proteases associated with a lung disease, for example, lung cancer and lung infections. In some embodiments, the disclosure provides compositions and methods for production of a lung disease signature and diagnosis of lung disease.