Predictive QRS detection and R-to-R timing systems and methods

US12178586B2 · kind B2 · utility

Assignees

• NuPulseCV, Inc. · US
• North Carolina State University · US

Inventors

• Robert Smith · Detroit, US
• Nagarjuna Reddy Chinta · Apex, US
• Ryan McCormick · Arlington, US
• Douglas E. Ivers · Cary, US
• Cranos M. Williams · Raleigh, US
• Divyakumar Mahiman Badheka · Raleigh, US
• Hubert Troy Nagle, Jr. · Durham, US
• Sai Bhargav Dasari · Raleigh, US
• Shamim Samadi · San Jose, US

Key dates

• Filing date: Mar 29, 2022
• Grant date: Dec 31, 2024
• Expiry date: Mar 29, 2042

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61M2230/06
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

The present disclosure is directed towards systems and methods built for predictively timing the inflation and/or deflation of an intra-aortic balloon pump. A controller operates in three states: (1) initialization state, (2) learning state, and (3) peak detection state. The controller decomposes a patient's electrocardiogram signal to a power signal. It then learns characteristics of the patient's electrocardiogram signal during the learning state and computes adaptive threshold parameter values. During the peak detection state, the controller applies the learnt threshold parameter values on a current electrocardiogram signal to identify occurrence and timings of R peaks in the electrocardiogram signal. The R-to-R peak timings are then used to trigger inflation of an intra-aortic balloon pump.