Patent · US Active

Antibody-drug conjugate, and intermediate thereof, preparation method therefor, and application thereof

US12178880B2 · kind B2 · utility

0Cited by

1References

6Claims

0Family size

Assignee

SHANGHAI FUDAN-ZHANGJIANG BIO-PHARMACEUTICAL CO., LTD. · CN

Inventors

Qingsong GUO · Chengdu, CN
Yijun SHEN · Shanghai, CN
Tong YANG · Shanghai, CN
Bin BAO · Shanghai, CN
Bei GAO · Shanghai, CN
Fang WU · Shanghai, CN
Jun Xu · Gaithersburg, US

Key dates

Filing date	Dec 4, 2020
Grant date	Dec 31, 2024
Priority date	—
Expiry date	Dec 4, 2040

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K16/32
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

An antibody-drug conjugate, and an intermediate thereof, a preparation method therefor, and an application thereof. Provided is an antibody-drug conjugate as represented by formula I. The compound has good targetability, has a good inhibitory effect on HER3-positive tumor cells, and has good druggability and high safety. The antibody-drug conjugate has an inhibitory effect on HER3, has an inhibitory effect on SK-BR-3 and SW620 cells, and also has a good inhibitory effect on at least one of 22Rv1, LNCaP, NCI-H820, OVCAR-8, and HCC827 cells.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.