Patent · US Active

Twin-screw dry granulation for producing solid formulations

US12178912B2 · kind B2 · utility

0Cited by

8References

10Claims

0Family size

Assignees

R.P. Scherer Technologies, LLC · US
UNIVERSITY OF MISSISSIPPI · US

Inventors

Sampada Bhaskar Upadhye · Princeton, US
Ronald Vladyka · Raritan, US
Michael A. Repka · Oxford, US
Jun-Bom Park · Seoul, KR
Roshan Vijay Tiwari · Fryeburg, US
Hemlata Gunga Patil · Fryeburg, US
Joseph Thomas Morott, Jr. · Morgantown, US
Wenli Lu · Shanghai, CN

Key dates

Filing date	Dec 5, 2022
Grant date	Dec 31, 2024
Priority date	—
Expiry date	Jan 5, 2043

Classification

Technology area (CPC B)Performing Operations; Transporting
CPC primaryB29C48/92
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A dry granulation process using a twin-screw extruder for granulating a powder mixture which includes at least one active ingredient and at least one carrier. The process includes steps of kneading the powder mixture in the screw barrel of the twin-screw extruder at a barrel temperature below a melting point of the at least one active ingredient and a melting point or a glass transition temperature of the at least one carrier to provide a kneaded powder mixture, and extruding the kneaded powder mixture to form granules. Granules and tablets produced using the dry granulation process in the twin-screw extruder are also provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.