Method of lyophilizing lipid nanoparticles
US12178921B2 · kind B2 · utility
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Key dates
| Filing date | Aug 13, 2021 |
| Grant date | Dec 31, 2024 |
| Priority date | — |
| Expiry date | Aug 13, 2041 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/0073
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods of preparing lyophilized lipid nanoparticle-nucleic acid compositions are provided. The methods comprise preparing a suspension of lipid nanoparticles with a monosaccharide and one or more excipients selected from thiosulfate, potassium sorbate, sodium benzoate, and iodixanol. Lyophilized lipid nanoparticle-nucleic acid compositions and methods of reconstituting and administering the same are further provided.
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