Systems and methods for biochemical analysis including a base instrument and a removable cartridge

US12179190B2 · kind B2 · utility

Assignee

• Illumina, Inc. · US

Inventors

• Alex Aravanis · San Francisco, US
• Boyan Boyanov · Portland, US
• M. Shane Bowen · Encinitas, US
• Dale Buermann · San Diego, US
• Alexander Hsiao · Los Angeles, US
• Behnam Javanmardi · San Francisco, US
• Tarun Khurana · San Diego, US
• Poorya Sabounchi · Pleasant Hill, US
• Hai Quang Tran · San Diego, US

Key dates

• Filing date: Dec 22, 2022
• Grant date: Dec 31, 2024
• Expiry date: Dec 22, 2042

Classification

• Technology area (CPC F): Mechanical Engineering; Lighting; Heating
• CPC primary: F16K2099/0084
• WIPO field: Mechanical elements
• WIPO sector: Mechanical engineering

Abstract

Systems and methods for conducting designated reactions utilizing a base instrument and a removable cartridge. The removable cartridge includes a fluidic network that receives and fluidically directs a biological sample to conduct the designated reactions. The removable cartridge also includes a flow-control valve that is operably coupled to the fluidic network and is movable relative to the fluidic network to control flow of the biological sample therethrough. The removable cartridge is configured to separably engage a base instrument. The base instrument includes a valve actuator that engages the flow-control valve of the removable cartridge. A detection assembly held by at least one of the removable cartridge or the base instrument may be used to detect the designated reactions.