N/O-linked degrons and degronimers for protein degradation
US12180225B2 · kind B2 · utility
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7References
19Claims
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Key dates
| Filing date | Oct 3, 2022 |
| Grant date | Dec 31, 2024 |
| Priority date | — |
| Expiry date | Oct 3, 2042 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG07F17/3288
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention provides Degronimers that have E3 Ubiquitin Ligase targeting moieties (Degrons) that can be linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation. The invention also provides Degrons that can be used to treat disorders mediated by cereblon or an Ikaros family protein, and methods of use and compositions thereof as well as methods for their preparation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.