Patent · US Active

Compositions and methods for derepressing RE1 silencing transcription factor target genes

US12180255B2 · kind B2 · utility

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20Claims
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Assignee

Inventors

Key dates

Filing dateNov 20, 2020
Grant dateDec 31, 2024
Priority date—
Expiry dateJan 31, 2041

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07K2319/06
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

The invention relates to compounds, compositions, and methods for derepressing RE1 silencing transcription factor (REST) target genes are provided. In particular, a peptide having the sequence TEDLEPPEPPLPKEN (SEQ. ID NO: 1) and EDLEPPEPPLPK (SEQ. ID NO: 15), or the reversed sequences made of D-amino acids (retro inverted, RI) nekplppeppeldet (SEQ ID NO: 16) and kplppeppelde (SEQ ID NO: 17), are disclosed for inhibiting REST activity. The peptides are useful to treat, prevent, or ameliorate conditions such as traumatic brain injury, epilepsy, dementia, Huntington's Disease (HD), chronic pain, brain cancer (including glioblastoma multiforme), pancreatic cancer; diabetes, and peripheral nerve injury.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.