System, method and computer-accessible medium for detecting functional disorder(s) or aging progression in magnetic resonance imaging

US12182969B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Jia Guo · Hangzhou City, CN
• Scott A. Small · Millerton, US

Key dates

• Filing date: Jun 15, 2021
• Grant date: Dec 31, 2024
• Expiry date: Jun 15, 2041

Classification

• Technology area (CPC G): Physics
• CPC primary: G06T2207/30016
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

An exemplary system, method, and computer-accessible medium for detection of functional disorder(s) or aging progression of patient(s) can be provided which can include, for example, receiving magnetic resonance imaging (MRI) information of the portion(s), generating gadolinium (“Gd”) enhanced map(s) based on the MRI information using a machine learning procedure(s), and detecting the functional disorder(s) or aging progression of the patient(s) based on the Gd enhanced map(s). The Gd enhanced map(s) can be a full dosage Gd enhanced map which can be a full dosage Gd enhanced cerebral blood volume map(s). The machine learning procedure can be a convolutional neural network. The MRI information can include (i) a low-dosage Gd MRI scan(s), and/or (ii) a Gd-free MRI scan(s). Functional disorder(s) or age progression can include a neurodegenerative disease, a neuropsychiatric disease, a neurodevelopment disorder or aging.