Methods of treating or preventing cancer with an agent that depletes tregs and a checkpoint inhibitor

US12186376B2 · kind B2 · utility

Assignee

• THE JOHNS HOPKINS UNIVERSITY · US

Inventors

• William R. Bishai · Baltimore, US
• John R. Murphy · Cambridge, US
• Drew M. Pardoll · Silver Spring, US
• Laurene Cheung · Baltimore, US
• Juan Fu · Timonium, US
• Pankaj Kumar · Madison, US
• Amit Kumar · San Ramon, US
• Sadiya Parveen · Baltimore, US
• Cynthia K. Bullen · Baltimore, US
• Vijayan Sambasivam · Puducherry, IN
• Sumit Siddharth · Baltimore, US
• Dipali Sharma · Baltimore, US

Key dates

• Filing date: Mar 6, 2019
• Grant date: Jan 7, 2025
• Expiry date: Dec 27, 2041

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2039/876
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is related to a method of treating or preventing cancer in a subject comprising administering to a subject having cancer or prone of getting cancer a first agent that depletes the subject's regulatory T cells (Tregs); followed by administering to the subject a second agent comprising a checkpoint inhibitor.