Non-ionic PVP-PLA block copolymers and liquid pharmaceutical compositions derived therefrom
US12186398B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 2, 2022 |
| Grant date | Jan 7, 2025 |
| Priority date | — |
| Expiry date | Mar 5, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08G2261/126
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
There are provided PVP-PLA block copolymers as defined in Formula (1): I wherein, x is an initiator alcohol having a boiling point greater than I 45° C., n is, on average, from 20 and 40, and m is, on average, from 10 and 40, wherein the block copolymers have a number average molecular weight (Mn) of at least 3000 Da. Polymers demonstrating flexibility in formulating multiple low solubility active pharmaceutical ingredients (APis) are described. Liquid and dry pharmaceutical formulations comprising an API are described, along with delivery methods, uses, and kits. APis may include, e.g. 11urbiprofon, celecoxib, acetaminophen, or propofol. Also provided is a method of synthesizing the PVP-PLA block copolymers by (i) initiating polymerization of D,L-Lactide from the initiator alcohol x to form poly(lactic acid), adding a xanthate to form a PLA macroinitiator, and polymerizing NVP onto the PLA macroinitiator, by controlled polymerization, to form the block copolymer compound of Formula (I).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.