SIRP α, SIRP β 1, and SIRP γ antibodies and uses thereof

US12187797B2 · kind B2 · utility

Assignee

• Electra Therapeutics, Inc. · US

Inventors

• Sandip Panicker · South San Francisco, US
• Adam David ROSENTHAL · South San Francisco, US
• Eileen Lingshu ROSE · South San Francisco, US

Key dates

• Filing date: Feb 28, 2024
• Grant date: Jan 7, 2025
• Expiry date: Feb 28, 2044

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Provided herein are antibodies that bind signal regulatory protein gamma (SIRPγ), as well as SIRPα and/or SIRPβ1, and methods of using such antibodies (referred to as SIRP antibodies). In some embodiments, the SIRP antibodies are human monoclonal antibodies that bind human SIRPγ as well as SIRPα and/or SIRPβ1. In some embodiments, the SIRP antibodies provided herein are useful for treating a disease or condition associated with overactivation and/or hyperproliferation of lymphocytes, myeloid cells, or a combination thereof, or a disease or condition associated with SIRPα, SIRPβ1 and/or SIRPγ activity.