Sensing of protein-protein interaction
US12190509B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 26, 2022 |
| Grant date | Jan 7, 2025 |
| Priority date | — |
| Expiry date | Jul 19, 2043 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG06T2210/12
- WIPO fieldComputer technology
- WIPO sectorElectrical engineering
Abstract
A composite image is accessed that comprises a plurality of complex images of samples of a protein-protein complex comprising a first protein and a second protein. The composite image is masked to generate a masked portion and an unmasked portion. A first three-dimensional (3d) shape of the first protein and a second 3d shape of the second protein is accessed. A plurality of docking models are accessed that each define a candidate pose-pair. For each docking model, the first 3d shape, the second 3d shape, and the candidate pose-pair are applied to generate, for the docking model, a corresponding fitment score that describes a goodness-of-fit between the pose-pair and the docking model. One of the docking models is selected as a sensed model for the protein-protein complex based on the fitment scores.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.