Systems and methods for classifying patients with respect to multiple cancer classes
US12191000B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 6, 2023 |
| Grant date | Jan 7, 2025 |
| Priority date | — |
| Expiry date | Mar 11, 2043 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16H70/60
- WIPO fieldComputer technology
- WIPO sectorElectrical engineering
Abstract
Technical solutions for classifying patients with respect to multiple cancer classes are provided. The classification can be done using cell-free whole genome sequencing information from subjects. A reference set of subjects is used to train classifiers to recognize genomic markers that distinguish such cancer classes. The classifier training includes dividing the reference genome into a set of non-overlapping bins, applying a dimensionality reduction method to obtain a feature set, and using the feature set to train classifiers. For subjects with unknown cancer class, the trained classifiers provide probabilities or likelihoods that the subject has a respective cancer class for each cancer in a set of cancer classes. The present disclosure thus describes methods to improve the screening and detection of cancer class from among several cancer classes. This serves to facilitate early and appropriate treatment for subjects afflicted with cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.