Process for preparing filled hard-shell capsules with cellulose or starch-based coatings with a capsule-filling machine

US12193993B2 · kind B2 · utility

Assignee

• Evonik Operations GmbH · DE

Inventors

• Vinay K. Jain · Dallas, US
• Ashish Guha · Kalyan-Dombivli, IN
• Shraddha Joshi · Navi Mumbai, IN
• Felix Hofmann · Darmstadt, DE
• Bettina Hölzer · Leverkusen, DE
• Hans Bär · Michelstadt, DE

Key dates

• Filing date: Apr 30, 2020
• Grant date: Jan 14, 2025
• Expiry date: Nov 28, 2041

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/4891
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A process can be used for preparing a polymer coated hard-shell capsule, filled with a fill containing a biologically active ingredient. The hard-shell capsule contains a body and a cap, and in a closed state, the cap overlaps the body in a pre-locked state or a final-locked state. The material of the body and cap contains an ethyl-, methyl-, or propyl-ether of cellulose, starch, or pullulan. The hard-shell capsule is coated with a coating layer, containing one or more anionic cellulose(s), ethyl cellulose, and/or one or more starches comprising at least 35% by weight of amylose, where the coating layer is present in an amount of about 1 to 5.8 mg/cm2. The process involves providing the polymer-coated hard-shell capsule in the pre-locked state to a capsule-filling machine, separating the body and the cap, filling the body with the fill, and rejoining the body and the cap in the final-locked state.