Pyrimidine tricyclic enone derivatives for inhibition of ROR-gamma and other uses
US12195443B2 · kind B2 · utility
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49References
35Claims
0Family size
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Key dates
| Filing date | Jan 18, 2022 |
| Grant date | Jan 14, 2025 |
| Priority date | — |
| Expiry date | Jan 18, 2042 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed herein are compounds of the formulas: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to inhibit RORγ and/or reduce the expression of IL-17. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or autoimmune disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.