Methods and materials for assessing and treating cancer

US12195803B2 · kind B2 · utility

Assignees

• THE JOHNS HOPKINS UNIVERSITY · US
• The Board of Regents of the University of Texas System · US
• The Research Foundation for The State University of New York · US

Inventors

• Bert Vogelstein · Baltimore, US
• Kenneth W. Kinzler · Baltimore, US
• Joshua David Cohen · Baltimore, US
• Nickolas Papadopoulos · Towson, US
• Anne Marie Lennon · Baltimore, US
• Cristian Tomasetti · Baltimore, US
• Yuxuan Wang · Baltimore, US
• Georges Jabboure Netto · Baltimore, US
• Rachel Karchin · Towson, US
• Christopher Douville · Baltimore, US
• Samir Hanash · Ann Arbor, US
• Simeon Springer · Baltimore, US
• Arthur Grollman · Port Jefferson, US
• Kathleen Dickman · Albany, US

Key dates

• Filing date: Aug 7, 2018
• Grant date: Jan 14, 2025
• Expiry date: Jun 10, 2039

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/60
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Provided herein are methods and materials for detecting and/or treating subject (e.g. a human) having cancer. In some embodiments, methods and materials for identifying a subject as having cancer (e.g., a localized cancer) are provided in which the presence of member(s) of two or more classes of biomarkers are detected. In some embodiments, methods and materials for identifying a subject as having cancer (e.g. a localized cancer) are provided in which the presence of member(s) of at least one class of biomarkers and the presence of aneuploidy are detected. In some embodiments, methods described herein provide increased sensitivity and/or specificity in the detection of cancer in a subject (e.g. a human).