Devices and systems with integrated electrodes or optical elements for monitoring cell cultures and related methods
US12196741B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 27, 2020 |
| Grant date | Jan 14, 2025 |
| Priority date | — |
| Expiry date | Mar 7, 2042 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/48735
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A scalable, real-time, label-free, electrode- or optical-based cell monitoring system for integration into a cell culture incubator is described herein. An example system includes (1) cell culture consumables with integrated electrodes and/or optics for growing and monitoring cells, (2) incubator trays for consumable organization and recording, and (3) a system console, external to the incubator, for connecting multiple incubator trays. Without perturbing the cell culture, the system is capable of monitoring multiple culture attributes for each cell culture consumable simultaneously. These attributes can include, but are not limited to, cell growth, proliferation, morphology, media pH, or media oxygen. The system can support multiple trays, which permits monitoring dozens to hundreds of consumables simultaneously, including a mixture of consumables of various sizes. In addition to monitoring adherent cells, the disclosed technology can be readily adapted for monitoring of cell suspensions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.