Methods and compositions for treatment of pain using capsaicin
US12201594B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 4, 2021 |
| Grant date | Jan 21, 2025 |
| Priority date | — |
| Expiry date | Jun 4, 2041 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61F2007/0042
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides methods and compositions for treatment of pain, such as joint pain, using capsaicin in a procedure that attenuates transient burning sensation experienced by patients due to capsaicin administration. The methods desirably provide relief from joint pain, such as osteoarthritic knee joint pain, for an extended duration, such as at least about 3 months, 6 months, 9 months, or 1 year. To attenuate the adverse side effect of a transient burning sensation caused by capsaicin-induced neuronal excitation, the methods utilize a cooling article, such as a material wrap cooled via a circulating fluid, to reduce the temperature of tissue to be exposed to capsaicin to within a certain range for certain durations of time, optionally in combination with administering a local anesthetic agent, resulting in the substantial reduction or even elimination of transient burning sensation caused by capsaicin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.