Patent · US Active

Conjugation of lipophilic albumin-binding moiety to RNA for improved carrier-free in vivo pharmacokinetics and gene silencing

US12201644B2 · kind B2 · utility

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1References

3Claims

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Assignee

VANDERBILT UNIVERSITY · US

Inventors

Craig L. Duvall · Nashville, US
Samantha M. Sarett · Nashville, US
Thomas A. Werfel · Nashville, US

Key dates

Filing date	Sep 14, 2021
Grant date	Jan 21, 2025
Priority date	—
Expiry date	Sep 14, 2041

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2320/32
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Provided herein are compounds and methods for gene silencing. The compound includes a RNA directly conjugated to an albumin-binding group. The method includes administering a compound comprising a RNA directly conjugated to an albumin-binding group to a subject in need thereof.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.