Intracellular delivery of biomolecules to induce tolerance
US12201652B2 · kind B2 · utility
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35References
37Claims
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Key dates
| Filing date | May 3, 2017 |
| Grant date | Jan 21, 2025 |
| Priority date | — |
| Expiry date | Feb 9, 2040 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/64
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides methods for inducing tolerance and/or suppressing an immune response to an antigen by passing a cell suspension containing an anucleate cell through a constriction, wherein the constriction deforms the cell thereby causing a perturbation of the cell such that an antigen and/or tolerogenic factor enters the cell. In some embodiments, the anucleate cell is delivered to an individual and the antigen is delivered to and processed in a tolerogenic environment to induce tolerance and/or suppress an immune response to the antigen.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.