Patent · US Active

Amanitin conjugates

US12201693B2 · kind B2 · utility

0Cited by

1References

5Claims

0Family size

Assignee

Heidelberg Pharma Research GmbH · DE

Inventors

Christian Lutz · Kassel, DE
Jan Anderl · Herchenrode, DE
Christoph Mueller · Birkenau, DE
Werner Simon · Seeheim-Jugenheim, DE
Susanne Werner-Simon · Hüffelsheim, DE
Torsten Hechler · Ladenburg, DE
Michael Kulke · Ladenburg, DE

Key dates

Filing date	Feb 27, 2023
Grant date	Jan 21, 2025
Priority date	—
Expiry date	Feb 27, 2043

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K16/30
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention relates to a conjugate comprising (a) an amatoxin comprising (i) an amino acid 4 with a 6′-deoxy position; and (ii) an amino acid 8 with an S-deoxy position; (b) a target-binding moiety; and (c) optionally a linker linking said amatoxin and said target-binding moiety. The invention furthermore relates to a pharmaceutical composition comprising such conjugate.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.