Pyrimidine derivative and preparation process and use thereof
US12202820B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Sep 10, 2019 |
| Grant date | Jan 21, 2025 |
| Priority date | — |
| Expiry date | Oct 4, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/05
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention discloses a novel pyrimidine derivative and a preparation process thereof and a use thereof in anti-tumor drugs. It is demonstrated through the tests on anti-tumor activity at the cellular level (tumor cells expressed with c-Met) that, through the introduction of a chiral structure in the molecule, the introduction of an isotope of hydrogen (deuterium) at the sites that are prone to metabolism in the molecule, and the introduction of atoms or groups such as sulfur, selenium and sulfoxide in the molecule, the compounds of the invention have excellent anti-tumor activities, and the stabilities of the anti-tumor compounds are significantly improved.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.