Patent · US Active

Fusion proteins for improved precision in base editing

US12203077B2 · kind B2 · utility

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0References

13Claims

0Family size

Assignee

SHANGHAITECH UNIVERSITY · CN

Inventors

Jia Chen · Changhua City, TW
Xingxu Huang · Shanghai, CN
Li Yang · Shanghai, CN
Bei Yang · Shiwen, TW
Xiaosa Li · Shanghai, CN
Ying-Tzung Wang · Hsinchu, TW
Yajing Liu · Hangzhou City, CN

Key dates

Filing date	Aug 28, 2018
Grant date	Jan 21, 2025
Priority date	—
Expiry date	Aug 9, 2040

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y305/04005
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Provided are base editors containing a cytidine and a catalytically inactive version of Lachnospiraceae bacterium Cpf1 (LbCpf1). The new base editors have greatly improved editing efficiency and fidelity as compared to Cas9-based base editors, and have different editing windows.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.